| Identification | Back Directory | [Name]
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol | [CAS]
440122-66-7 | [Synonyms]
WAY 200070
WAY200070;WAY 200070
7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C13H8BrNO3 | [MDL Number]
MFCD16618385 | [MOL File]
440122-66-7.mol | [Molecular Weight]
306.11 |
| Chemical Properties | Back Directory | [Boiling point ]
463.6±35.0 °C(Predicted) | [density ]
1.720±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: ≥20mg/mL | [form ]
solid | [pka]
7.26±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
WAY 200070 is an aryl diphenolic azole and a selective ERβ agonist. This compound is suitable for estrogen receptor signaling research. | [Biological Activity]
WAY-200070 is a selective estrogen receptor agonist with IC50 of 2.3 nM. | [in vivo]
Administration of WAY-200070 (30 mg/kg sc) causes nuclear translocation of ERRβ receptors in WT mice. Administration of it produces a delayed 50% increase in dopamine in the striatum of wild type mice. It reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070 , shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test. < /div> | [target]
IC50: 2.3 nM (ERRβ), 155 nM (ERRα) | [IC 50]
ERβ: 2.3 nM (IC50); ERα: 155 nM (IC50) | [storage]
Store at RT |
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