| Identification | Back Directory | [Name]
2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]- | [CAS]
1432494-65-9 | [Synonyms]
2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]- | [Molecular Formula]
C60H120N4O6 | [MOL File]
1432494-65-9.mol | [Molecular Weight]
993.62 |
| Chemical Properties | Back Directory | [Boiling point ]
1003.2±65.0 °C(Predicted) | [density ]
0.963±0.06 g/cm3(Predicted) | [solubility ]
Chloroform: soluble; Ethanol: soluble; Methanol: soluble | [form ]
Liquid | [pka]
12.87±0.60(Predicted) | [color ]
Colorless to light yellow | [InChIKey]
ZISVTYVLWSZJAL-UHFFFAOYSA-N | [SMILES]
N1C(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C(=O)NC(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C1=O |
| Hazard Information | Back Directory | [Description]
CKK-E12 is an ionizable lipid. It is useful for Development of Lipidoid Nanoparticles for siRNA, mRNA, and vaccine delivery. | [Uses]
CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo, | [in vivo]
CKK-E12 delivers siRNA in mice, rats and primates (ED50 is 0.002, 0.01 and 0.3 mg/kg, respectively)[1].
| [References]
[1] Dong Y, Love KT, Dorkin JR, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [published correction appears in Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753].?Proc Natl Acad Sci U S A. 2014;111(11):3955-3960. DOI:10.1073/pnas.1322937111
[2] Oberli MA, Reichmuth AM, Dorkin JR, et al. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017;17(3):1326-1335. DOI:10.1021/acs.nanolett.6b03329
[3] Hatit MZC, et al. Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nat Nanotechnol. 2022 Mar;17(3):310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7. DOI:10.1038/s41565-021-01030-y |
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