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LOE 908 Hydrochloride is a isoquinoline derivative and a cation channel blocker. LOE 908 Hydrochloride is a neuroprotective agent. | [in vivo]
LOE 908 (4 or 2 mg/kg followed by 160 or 80 mg/kg; i.v.) hydrochloride attenuates acute neuromotor dysfunction in rats[2]. | Animal Model: | Adult male Sprague-Dawley rats, lateral fluid percussion brain injury model[2] | | Dosage: | 4 mg/kg bolus followed by 160 mg/kg over 24 h or 2 mg/kg bolus followed by 80 mg/kg over 24 h | | Administration: | Intravenous administration | | Result: | Significantly improved neuromotor function at 48 h postinjury when compared to vehicle treatment. |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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