| Identification | Back Directory | [Name]
6.beta.-Naltrexol-d3 | [CAS]
1435727-11-9 | [Synonyms]
6β-Naltrexol-d3
6.beta.-Naltrexol-d3
6β-Naltrexol-d3 (CRM)
6.beta.-Naltrexol-d3 (CRM)
(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-d3-morphinan-3,6,14-triol
(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-d3-morphinan-3,6,14-triol | [Molecular Formula]
C20H22D3NO4 | [MDL Number]
MFCD32672122 | [MOL File]
1435727-11-9.mol | [Molecular Weight]
346.435 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
A neat solid | [Major Application]
forensics and toxicology | [InChIKey]
JLVNEHKORQFVQJ-ZNMQZXPKSA-N | [SMILES]
[2H]C([2H])(N1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@]2(O)CC[C@H]4O)c35)C6([2H])CC6 |
| Safety Data | Back Directory | [WGK Germany ]
WGK 2 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 |
| Hazard Information | Back Directory | [Description]
6β-Naltrexol-d3 (Item No. 18350) is an analytical reference material intended for use as an internal standard for the quantification of 6β-naltrexol by GC- or LC-MS. 6β-Naltrexol is the major metabolite of naltrexone (Item Nos. ISO60192 | 15520). It is a neutral μ-opioid receptor antagonist (Ki = 94 pM). This product is intended for research and forensic applications. | [Uses]
6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit[1][2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Cone EJ, et al. Biosynthesis, isolation, and identification of 6-beta-hydroxynaltrexone, a major human metabolite of naltrexone. J Pharm Sci. 1975 Apr;64(4):618-21. DOI:10.1002/jps.2600640409
[3] Yancey-Wrona J, et al. 6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study. Pain Med. 2011 Dec;12(12):1727-37. DOI:10.1111/j.1526-4637.2011.01279.x |
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| Company Name: |
TOSUN PHARM
|
| Tel: |
61855200 13326451905 |
| Website: |
www.toref.cn/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|