| Identification | Back Directory | [Name]
N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide | [CAS]
143655-58-7 | [Synonyms]
N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrah
ydronaphthalen-1-yl)acetamide | [Molecular Formula]
C13H14FNO2 | [MDL Number]
MFCD31716093 | [MOL File]
143655-58-7.mol | [Molecular Weight]
235.25 |
| Chemical Properties | Back Directory | [Boiling point ]
443.9±45.0 °C(Predicted) | [density ]
1.262±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
Solid | [pka]
13.73±0.20(Predicted) | [color ]
Off-white to light brown | [InChI]
InChI=1S/C13H14FNO2/c1-7-9-4-3-5-12(17)13(9)11(6-10(7)14)15-8(2)16/h6H,3-5H2,1-2H3,(H,15,16) | [InChIKey]
PSNRFAKPOCIEDV-UHFFFAOYSA-N | [SMILES]
C(NC1=C2C(CCCC2=O)=C(C)C(F)=C1)(=O)C |
| Hazard Information | Back Directory | [Uses]
Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs). | [IC 50]
Camptothecins | [References]
[1] Zhang, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998 A. 2020-07-31.
[2] Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. DOI:10.1111/j.1349-7006.1995.tb02468.x |
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YJ Pharma Gold
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13962794339 |
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