| Identification | Back Directory | [Name]
N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide | [CAS]
143655-70-3 | [Synonyms]
N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
Acetamide, N,N'-(3-fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1,7-naphthalenediyl)bis- (9CI) | [Molecular Formula]
C15H17FN2O3 | [MDL Number]
MFCD31657913 | [MOL File]
143655-70-3.mol | [Molecular Weight]
292.31 |
| Chemical Properties | Back Directory | [Boiling point ]
596.8±50.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.55±0.40(Predicted) | [color ]
Off-white to gray | [InChI]
InChI=1S/C15H17FN2O3/c1-7-10-4-5-12(17-8(2)19)15(21)14(10)13(6-11(7)16)18-9(3)20/h6,12H,4-5H2,1-3H3,(H,17,19)(H,18,20) | [InChIKey]
UNQLSBJKEGXCGH-UHFFFAOYSA-N | [SMILES]
C1(NC(=O)C)=C2C(CCC(NC(=O)C)C2=O)=C(C)C(F)=C1 |
| Hazard Information | Back Directory | [Uses]
Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs). | [IC 50]
Camptothecins | [References]
[1] Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10.
[2] Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. DOI:10.1111/j.1349-7006.1995.tb02468.x |
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