| Identification | Back Directory | [Name]
Carbamic acid, N-[(2S,3R)-2-methyl-4-oxo-3-oxetanyl]-, [1,1'-biphenyl]-4-ylmethyl ester | [CAS]
1439366-66-1 | [Synonyms]
NAAA-IN-1
Carbamic acid, N-[(2S,3R)-2-methyl-4-oxo-3-oxetanyl]-, [1,1'-biphenyl]-4-ylmethyl ester | [Molecular Formula]
C18H17NO4 | [MOL File]
1439366-66-1.mol | [Molecular Weight]
311.33 |
| Chemical Properties | Back Directory | [Boiling point ]
524.9±50.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.13±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NAAA-IN-1 (Compound 1) is a potent and selective inhibitor of NAAA with an IC50 of 7 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). NAAA-IN-1 has the potential for the research of inflammation and pain[1]. | [References]
[1] Malamas MS, et al. Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors. Bioorg Med Chem. 2020 Jan 1;28(1):115195. DOI:10.1016/j.bmc.2019.115195 |
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