| Identification | More | [Name]
5-PHENYLISOXAZOLE-3-CARBOXYLIC ACID | [CAS]
14441-90-8 | [Synonyms]
5-PHENYL-3-ISOXAZOLECARBOXYLIC ACID
5-PHENYLISOXAZOLE-3-CARBOXYLIC ACID
AKOS B019304
AKOS PAO-1380
ART-CHEM-BB B019304
CHEMBRDG-BB 4401205
SALOR-INT L482528-1EA
3-isoxazolecarboxylic acid, 5-phenyl- | [Molecular Formula]
C10H7NO3 | [MDL Number]
MFCD00464221 | [Molecular Weight]
189.17 | [MOL File]
14441-90-8.mol |
| Questions And Answer | Back Directory | [Synthesis]
The target compound 5-PHENYLISOXAZOLE-3-CARBOXYLIC ACID was prepared by hydrolysis using 5-phenyl-3-isoxazole carboxylic acid ester as the starting material [1]. The synthetic reaction formula is shown in the figure below: 
| [Uses]
5-Phenylacetic acid is a carboxylic acid derivative that can be used as an intermediate in organic synthesis. |
| Chemical Properties | Back Directory | [Melting point ]
160-164 °C(lit.) | [Boiling point ]
434.7±33.0 °C(Predicted) | [density ]
1.320 | [storage temp. ]
2-8°C | [solubility ]
soluble in Methanol | [form ]
Crystalline | [pka]
3.33±0.10(Predicted) | [color ]
White | [InChI]
InChI=1S/C10H7NO3/c12-10(13)8-6-9(14-11-8)7-4-2-1-3-5-7/h1-6H,(H,12,13) | [InChIKey]
XJYOBHXWBRKOQO-UHFFFAOYSA-N | [SMILES]
O1C(C2=CC=CC=C2)=CC(C(O)=O)=N1 | [CAS DataBase Reference]
14441-90-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
2
| [HazardClass ]
IRRITANT | [HS Code ]
2934999090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
5-Phenylisoxazole-3-carboxylic acid is a phenoxy compound, can be used in pharmaceutical research. | [Biological Activity]
5-phenylisoxazole-3-carboxylic acid and derivatives have the ability to inhibit xanthine oxidase (XO). XO is a key enzyme in the last two steps of purine metabolic pathway, catalyzing the oxidation of hypoxanthine to xanthine, and then to urid acid, which associated with gout and hyperuricemia. | [Safety]
5-Phenylisoxazole-3-carboxylic acid is a compound that is irritating to humans. It is acutely toxic if ingested. Skin contact causes skin irritation and may also trigger allergic skin reactions. Accidental contact with the eyes may cause severe eye irritation. Inhalation may cause allergic reactions, asthma symptoms or breathing difficulties. |
|
| Company Name: |
Wuhan Topule Gold
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+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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Shanghai Ennopharm Co., Ltd.
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+86 (21) 6435-5022 |
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www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm |
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