| Identification | More | [Name]
5-PHENYLISOXAZOLE-3-CARBOXYLIC ACID | [CAS]
14441-90-8 | [Synonyms]
5-PHENYL-3-ISOXAZOLECARBOXYLIC ACID
5-PHENYLISOXAZOLE-3-CARBOXYLIC ACID
AKOS B019304
AKOS PAO-1380
ART-CHEM-BB B019304
CHEMBRDG-BB 4401205
SALOR-INT L482528-1EA
3-isoxazolecarboxylic acid, 5-phenyl- | [Molecular Formula]
C10H7NO3 | [MDL Number]
MFCD00464221 | [Molecular Weight]
189.17 | [MOL File]
14441-90-8.mol |
| Questions And Answer | Back Directory | [Synthesis]
The target compound 5-PHENYLISOXAZOLE-3-CARBOXYLIC ACID was prepared by hydrolysis using 5-phenyl-3-isoxazole carboxylic acid ester as the starting material [1]. The synthetic reaction formula is shown in the figure below: 
| [Uses]
5-Phenylacetic acid is a carboxylic acid derivative that can be used as an intermediate in organic synthesis. |
| Chemical Properties | Back Directory | [Melting point ]
160-164 °C(lit.) | [Boiling point ]
434.7±33.0 °C(Predicted) | [density ]
1.320 | [storage temp. ]
2-8°C | [solubility ]
soluble in Methanol | [form ]
Crystalline | [pka]
3.33±0.10(Predicted) | [color ]
White | [InChI]
InChI=1S/C10H7NO3/c12-10(13)8-6-9(14-11-8)7-4-2-1-3-5-7/h1-6H,(H,12,13) | [InChIKey]
XJYOBHXWBRKOQO-UHFFFAOYSA-N | [SMILES]
O1C(C2=CC=CC=C2)=CC(C(O)=O)=N1 | [CAS DataBase Reference]
14441-90-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
2
| [HazardClass ]
IRRITANT | [HS Code ]
2934999090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
5-Phenylisoxazole-3-carboxylic acid is a phenoxy compound, can be used in pharmaceutical research. | [Biological Activity]
5-phenylisoxazole-3-carboxylic acid and derivatives have the ability to inhibit xanthine oxidase (XO). XO is a key enzyme in the last two steps of purine metabolic pathway, catalyzing the oxidation of hypoxanthine to xanthine, and then to urid acid, which associated with gout and hyperuricemia. |
|
| Company Name: |
Wuhan Topule Gold
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+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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Shanghai Ennopharm Co., Ltd.
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+86 (21) 6435-5022 |
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www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm |
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