144542-43-8

32315-10-9

5680-80-8

96751-61-0

General procedure for the synthesis of methyl 2-oxoxoxazolidine-4-carboxylate from tritiated gas and L-serine methyl ester hydrochloride: a THF solution of tritiated gas (60 mL, 11.4 g, 38.58 mmol, 1.0 eq.) was slowly added to a tetrahydrofuran (THF, 90 mL) suspension of L-serine methyl ester hydrochloride (6 g, 38.58 mmol). The reaction mixture was heated to reflux for 4 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by rapid chromatography on silica gel (eluent ratio: ethyl acetate/hexane = 3:1) to afford the target product methyl 2-oxoxoxazolidine-4-carboxylate (4.38 g, 78% yield) as a white solid.