| Identification | Back Directory | [Name]
VL285 | [CAS]
1448188-57-5 | [Synonyms]
VL285
VL-285; VL 285; VL285
2-Pyrrolidinecarboxamide, 1-[(2S)-2-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-3-methyl-1-oxobutyl]-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (2S,4R)- | [Molecular Formula]
C29H32N4O4S | [MOL File]
1448188-57-5.mol | [Molecular Weight]
532.65 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
VL285 is a potent VHL ligand with an IC50 of 0.34 μM[1]. | [IC 50]
VHL | [References]
[1] Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. DOI:10.1021/acschembio.5b00442 |
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