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1448188-57-5

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1448188-57-5 Structure

1448188-57-5 Structure
IdentificationBack Directory
[Name]

VL285
[CAS]

1448188-57-5
[Synonyms]

VL285
VL-285; VL 285; VL285
2-Pyrrolidinecarboxamide, 1-[(2S)-2-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-3-methyl-1-oxobutyl]-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (2S,4R)-
[Molecular Formula]

C29H32N4O4S
[MOL File]

1448188-57-5.mol
[Molecular Weight]

532.65
Chemical PropertiesBack Directory
[storage temp. ]

Sealed in dry,Store in freezer, under -20°C
[solubility ]

DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
[form ]

Solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

VL285 is a potent VHL ligand with an IC50 of 0.34 μM[1].
[IC 50]

VHL
[References]

[1] Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. DOI:10.1021/acschembio.5b00442
Spectrum DetailBack Directory
[Spectrum Detail]

VL285(1448188-57-5)1HNMR
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