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1448706-15-7

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1448706-15-7 Structure

1448706-15-7 Structure
IdentificationBack Directory
[Name]

2-Piperidinemethanol, 1-[2-[4-[[4-(3,4-dichlorophenyl)-2-thiazolyl]amino]phenyl]ethyl]-4-hydroxy-, (2R,4S)-
[CAS]

1448706-15-7
[Synonyms]

Amgen-23
2-Piperidinemethanol, 1-[2-[4-[[4-(3,4-dichlorophenyl)-2-thiazolyl]amino]phenyl]ethyl]-4-hydroxy-, (2R,4S)-
[Molecular Formula]

C23H25Cl2N3O2S
[MOL File]

1448706-15-7.mol
[Molecular Weight]

478.43
Chemical PropertiesBack Directory
[Boiling point ]

673.6±65.0 °C(Predicted)
[density ]

1.369±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

14.73±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor with IC50 values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used for researching anticancer[1].
[IC 50]

SphK1: 20 nM (IC50); SphK2: 1.6 μM (IC50)
[References]

[1] Gustin DJ, et al. Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4608-16. DOI:10.1016/j.bmcl.2013.06.030
Spectrum DetailBack Directory
[Spectrum Detail]

2-Piperidinemethanol, 1-[2-[4-[[4-(3,4-dichlorophenyl)-2-thiazolyl]amino]phenyl]ethyl]-4-hydroxy-, (2R,4S)-(1448706-15-7)1HNMR
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