| Identification | Back Directory | [Name]
Benzamide, N-methyl-2-[[4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl]amino]- | [CAS]
1448791-29-4 | [Synonyms]
PHM16
PHM-16
PHM 16
Benzamide, N-methyl-2-[[4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl]amino]- | [Molecular Formula]
C20H22N6O4 | [MOL File]
1448791-29-4.mol | [Molecular Weight]
410.43 |
| Hazard Information | Back Directory | [Description]
PHM16 is an ATP competitive inhibitor of FAK and FGFR2. | [Uses]
PHM16 is an ATP competitive inhibitor of FAK and FGFR2 (IC50: 0.4 μM and 0.37 μM, respectively), with direct potent anti-angiogenic activity[1]. | [IC 50]
FGFR2: 0.37 μM (IC50); FAK: 0.4 μM (IC50) | [References]
[1] Pascal Dao, et al. Inhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activities. Cancer Lett. 2014 Jun 28;348(1-2):88-99. DOI:10.1016/j.canlet.2014.03.007 |
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