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1449390-64-0

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1449390-64-0 Structure

1449390-64-0 Structure
IdentificationBack Directory
[Name]

MPEG5-Hydrazide
[CAS]

1449390-64-0
[Synonyms]

MPEG5-Hydrazide
H2N-PEG5-Hydrazide
[Molecular Formula]

C14H30N2O7
[MDL Number]

MFCD31706206
[MOL File]

1449390-64-0.mol
[Molecular Weight]

338.4
Chemical PropertiesBack Directory
[Boiling point ]

478.5±45.0 °C(Predicted)
[density ]

1.100±0.06 g/cm3(Predicted)
[pka]

12.82±0.35(Predicted)
Hazard InformationBack Directory
[Uses]

m-PEG6-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[Biological Activity]

m-PEG6-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[IC 50]

PEGs
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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