| Identification | Back Directory | [Name]
Z-NH-5(ethylene glycol)-acetic acid | [CAS]
1449390-66-2 | [Synonyms]
CbzNH-P5-CH2CO2H
Z-NH-PEG5-CH2COOH
CBZ-NH-PEG5-CH2COOH
CBZ-NH-PEG5-acetic acid
Z-NH-5(ethylene glycol)-acetic acid
5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(phenylmethyl) ester | [Molecular Formula]
C20H31NO9 | [MDL Number]
MFCD31656969 | [MOL File]
1449390-66-2.mol | [Molecular Weight]
429.46 |
| Hazard Information | Back Directory | [Uses]
Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
|
| Company Name: |
ChemPep, Inc.
|
| Tel: |
+1 (888) 615-9178 / (561) 791-8787 |
| Website: |
www.chempep.com |
| Company Name: |
T&W GROUP
|
| Tel: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
|