| Hazard Information | Back Directory | [Uses]
HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor with IC50s of 3-47 pM. HCV-IN-7 hydrochloride shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. HCV-IN-7 hydrochloride has anti-viral activity[1]. | [in vivo]
HCV-IN-7 hydrochloride (iv; 1 mg/kg) has a T1/2 of 2 hours, CL of 11 mL/min/kg, and a Vss of 2 L/kg for rats[1].
HCV-IN-7 hydrochloride (po; 10 mg/kg) has a Cmax of 1 μM and an AUClast of 6 μM for rats[1].
HCV-IN-7 hydrochloride (iv; 1 mg/kg) has a T1/2 of 4 hours, a CL of 6 mL/min/kg, and a Vss of 2 L/kg for dog[1].
HCV-IN-7 hydrochloride (po; 10 mg/kg) has a Cmax of 5 μM and an AUClast of 49 μM for dog[1].
| [References]
[1] Ramdas V, et al. Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate. J Med Chem. 2019 Dec 12;62(23):10563-10582. DOI:10.1021/acs.jmedchem.9b01562 |
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