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1449756-87-9

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1449756-87-9 Structure

1449756-87-9 Structure

Identification	Back Directory
[Name] HCV-IN-7 hydrochloride
[CAS] 1449756-87-9
[Synonyms] HCV-IN-7 hydrochloride
[Molecular Formula] C40H49ClN8O6S
[MOL File] 1449756-87-9.mol
[Molecular Weight] 805.39

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[Uses] HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor with IC50s of 3-47 pM. HCV-IN-7 hydrochloride shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. HCV-IN-7 hydrochloride has anti-viral activity[1].
[in vivo] HCV-IN-7 hydrochloride (iv; 1 mg/kg) has a T_1/2 of 2 hours, CL of 11 mL/min/kg, and a V_ss of 2 L/kg for rats^[1]. HCV-IN-7 hydrochloride (po; 10 mg/kg) has a C_max of 1 μM and an AUC_last of 6 μM for rats^[1]. HCV-IN-7 hydrochloride (iv; 1 mg/kg) has a T_1/2 of 4 hours, a CL of 6 mL/min/kg, and a V_ss of 2 L/kg for dog^[1]. HCV-IN-7 hydrochloride (po; 10 mg/kg) has a C_max of 5 μM and an AUC_last of 49 μM for dog^[1].
[References] [1] Ramdas V, et al. Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate. J Med Chem. 2019 Dec 12;62(23):10563-10582. DOI:10.1021/acs.jmedchem.9b01562

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Company Name:	RD International Technology Co., Limited
Telephone:	18024082417
Website:	www.ruidiresearch.com

Company Name:	TargetMol Chemicals Inc.
Telephone:	15002134094
Website:	https://www.targetmol.cn/

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