| Identification | Back Directory | [Name]
2-((1r,4r)-4-(4-(2-((4-(trifluoroMethoxy)benzyl)carbaMoyl)iMidazo[1,2-a]pyridin-6-yl)phenyl)cyclohexyl)acetic acid | [CAS]
1449779-49-0 | [Synonyms]
CS-2654
CS-2804
DGAT1-IN-1
DGAT1 inhibitor 1
2-((1r,4r)-4-(4-(2-((4-(trifluoroMethoxy)benzyl)carbaMoyl)iMidazo[1,2-a]pyridin-6-yl)phenyl)cyclohexyl)acetic acid
Cyclohexaneacetic acid, 4-[4-[2-[[[[4-(trifluoromethoxy)phenyl]methyl]amino]carbonyl]imidazo[1,2-a]pyridin-6-yl]phenyl]-, trans- | [Molecular Formula]
C30H28F3N3O4 | [MDL Number]
MFCD28167832 | [MOL File]
1449779-49-0.mol | [Molecular Weight]
551.56 |
| Chemical Properties | Back Directory | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 20 mg/mL (36.26 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
Powder | [pka]
4.72±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).
IC50 value: < 10 nM
Target: DGAT1 inhibitor
Imidazopyridine and imidazothiazole compounds as inhibitors of diacylglycerol o-acyltransferase type 1 enzyme and their preparation
By Kim, Dooseop; Bok, Juhan; Shin, Sunmi
From PCT Int. Appl. (2013), WO 2013119040 A1 20130815. | [References]
[1] Compounds as inhibitors of diacylglycerol o-acyltransferase type 1 enzyme , Patent: WO 2013119040 A1 |
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