| Identification | Back Directory | [Name]
GGKPDLRPCHPPCHYIPRPKPR | [CAS]
145038-84-2 | [Synonyms]
-disulfide
WAGLERIN I
cyclic(9-13)
Emtricitabine 6&rsquo
GGKPDLRPCHPPCHYIPRPKPR
trimeresuruswagleritoxini
Waglerin I, Trimeresurus wagleri
-prolyl-l-cysteinyl-l-histidyl-l-prolyl-l-prolyl-l-cysteinyl-l-histidyl-l-tyr
l-arginine,glycylglycyl-l-lysyl-l-prolyl-l-alpha-aspartyl-l-leucyl-l-arginyl-l
L-Arginine, glycylglycyl-L-lysyl-L-prolyl-L-α-aspartyl-L-leucyl-L-arginyl-L-prolyl-L-cysteinyl-L-histidyl-L-prolyl-L-prolyl-L-cysteinyl-L-histidyl-L-tyrosyl-L-isoleucyl-L-prolyl-L-arginyl-L-prolyl-L-lysyl-L-prolyl-, cyclic (9→13)-disulfide
L-Arginine, glycylglycyl-L-lysyl-L-prolyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-prolyl-L-cysteinyl-L-histidyl-L-prolyl-L-prolyl-L-cysteinyl-L-histidyl-L-tyrosyl-L-isoleucyl-L-prolyl-L-arginyl-L-prolyl-L-lysyl-L-prolyl-, cyclic (9-13)-disulfide | [Molecular Formula]
C112H175N37O26S2 | [MDL Number]
MFCD01074993 | [MOL File]
145038-84-2.mol | [Molecular Weight]
2519.95 |
| Chemical Properties | Back Directory | [density ]
1.57±0.1 g/cm3(Predicted) | [form ]
Solid | [color ]
White to off-white | [Sequence]
Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys-His-Pro-Pro-Cys-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg (Disulfide bridge: Cys9-Cys13) |
| Hazard Information | Back Directory | [Uses]
Waglerin-1, a 22-amino acid peptide, is a competitive antagonist of the muscle nicotinic receptor (nAChR)[1]. | [References]
[1] Brian E Molles, et al. Identification of Residues at the α and ε Subunit Interfaces Mediating Species Selectivity of Waglerin-1 for Nicotinic Acetylcholine Receptors. J Biol Chem. 2002 Feb 15;277(7):5433-40. DOI:10.1074/jbc.M109232200
[2] J H Ye, et al. Waglerin-1 inhibits GABAA current of neurons in the nucleus accumbens of neonatal rats. Brain Res. 1999 Aug 7;837(1-2):29-37. DOI:10.1016/s0006-8993(99)01668-6 |
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