| Identification | Back Directory | [Name]
TNU9056 | [CAS]
1450644-28-6 | [Synonyms]
TNU9056
Isothiazole, 5,5'-dithiobis-
1,2-Di(isothiazol-5-yl)disulfane
NU9056 1,2-Bis(isothiazol-5-yl)disulfane
TNU9056 1,2-Di(isothiazol-5-yl)disulfane
5-(1,2-thiazol-5-yldisulfanyl)-1,2-thiazole | [Molecular Formula]
C6H4N2S4 | [MOL File]
1450644-28-6.mol | [Molecular Weight]
232.37 |
| Chemical Properties | Back Directory | [Boiling point ]
209.2±40.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
<10mg/ml in DMSO | [form ]
Liquid | [pka]
2.44±0.38(Predicted) | [color ]
Yellow to brown | [InChI]
1S/C6H4N2S4/c1-3-7-9-5(1)11-12-6-2-4-8-10-6/h1-4H | [InChIKey]
MLRAMCAHIWHWRM-UHFFFAOYSA-N | [SMILES]
[s]1nccc1SSc2[s]ncc2 |
| Hazard Information | Back Directory | [Uses]
NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor. It inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Iy decreases proliferation of LNCaP cells and induces apoptosis via caspase activation. | [Biological Activity]
Cell permeable: yes''Primary Target
KAT5''Reversible: yes | [in vivo]
The mice are injected with Nu9056 (2 μg/g) and the hippocampus is collected 1 h later. Tip60 inhibition reduces H2A.Z binding at the -1 nucleosome of Arc, and the +1 nucleosome of Arc and Syp. Additionally, Nu9056 increases acetylation at the -1 nucleosome of Fos, Tacstd2, and Gria4, and the +1 nucleosome of Gria4[2]. | [storage]
Store at -20°C |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|