| Chemical Properties | Back Directory | [Boiling point ]
502.7±50.0 °C(Predicted) | [density ]
1.303±0.06 g/cm3(Predicted) | [solubility ]
DMF: 25 mg/ml
DMSO: 25 mg/ml
Ethanol: 10 mg/ml | [pka]
9.20±0.15(Predicted) |
| Hazard Information | Back Directory | [Description]
SP-8356 an anti-inflammatory synthetic verbenone derivative, is a potent, orally active cluster of differentiation 147 (CD147) inhibitor. SP-8356 inhibits CD147-cyclophilin A (CypA) interaction and reduces MMP-9 activity. SP-8356 exerts anti-breast cancer effects by inhibiting NF-κB signaling. | [References]
[1] K. PAHK. A novel CD147 inhibitor, SP-8356, reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligation[J]. Journal of Translational Medicine, 2019. DOI: 10.1186/s12967-019-2024-y
[2] KISOO PAHK. SP-8356, a Novel Inhibitor of CD147-Cyclophilin A Interactions, Reduces Plaque Progression and Stabilizes Vulnerable Plaques in apoE-Deficient Mice.[J]. International Journal of Molecular Sciences, 2019, 21 1. DOI: 10.3390/ijms21010095
[3] CHUNG JU . Discovery of novel (1S)-(−)-verbenone derivatives with anti-oxidant and anti-ischemic effects[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 19: Pages 5421-5425. DOI: 10.1016/j.bmcl.2013.07.038
[4] SUNAM MANDER. SP-8356, a (1S)-(-)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signaling.[J]. Scientific Reports, 2019: 6595. DOI: 10.1038/s41598-019-41224-y |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
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