| Identification | Back Directory | [Name]
2,9-Diazaspiro[5.5]undecan-1-one, 9-(4,6-dimethyl-2-pyrimidinyl)-2-[(5-methoxy-1H-indol-3-yl)methyl]- | [CAS]
1457940-75-8 | [Synonyms]
Orexin receptor antagonist 2
2,9-Diazaspiro[5.5]undecan-1-one, 9-(4,6-dimethyl-2-pyrimidinyl)-2-[(5-methoxy-1H-indol-3-yl)methyl]- | [Molecular Formula]
C25H31N5O2 | [MOL File]
1457940-75-8.mol | [Molecular Weight]
433.55 |
| Chemical Properties | Back Directory | [Boiling point ]
716.3±70.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 62.5 mg/mL (144.16 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
16?+-.0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pKis of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia[1]. | [storage]
Store at -20°C | [References]
[1] Betschart C, et al. Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J Med Chem. 2013;56(19):7590-7607. DOI:10.1021/jm4007627 |
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