| Hazard Information | Back Directory | [Description]
EP009 is a novel, selective, and orally active inhibitor of JAK3, inducing therapeutic response in T-cell malignancies. | [Uses]
EP009 is a JAK3 inhibitor that selectively inhibits IL-2-mediated JAK3 tyrosine phosphorylation (IC50=10-20 μM in Kit225 cells) without affecting IL-3-induced JAK2 phosphorylation (up to 50 μM in BaF/3 cells). EP009 significantly reduced Kit225 cell viability (72 h, LD50=5.0 μM) while having no effect on BaF/3 cells.[1]. | [References]
[1] Inhibition of JAK3 with a novel, selective, and orally active small molecule induces therapeutic response in T-cell malignancies |
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