| Chemical Properties | Back Directory | [alpha ]
D20 +9.6° (c = 0.29 in ethanol) | [Boiling point ]
898.3±65.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [pka]
1.49±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Zaragozic acid C (L-697350) is a potent sterol synthase inhibitor with potential antitumor activity. Zaragozic acid C contains multiple hydroxyl and alkyl substituents in its chemical structure, demonstrating complex functionalization capabilities. The synthesis of zaragozic acid C involves a photochemical C(sp3)-H acylation reaction, which resolves the challenging carbon substitution problem in the synthesis[1]. | [Definition]
ChEBI: Zaragozic acid C is a polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase. It has a role as an EC 2.5.1.21 (squalene synthase) inhibitor and a fungal metabolite. It is an acetate ester, a cyclic ketal, an oxabicycloalkane, a polyketide, a tertiary alcohol and a tricarboxylic acid. | [References]
[1] Total Synthesis of Zaragozic Acid C: Implementation of Photochemical C(sp3)-H Acylation DOI:10.1021/jacs.6b13263 |
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