| Identification | Back Directory | [Name]
Zaragozic acid D | [CAS]
155179-14-9 | [Synonyms]
Zaragozic acid D
L-glycero-D-altro-Pentadec-14-en-7-ulo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13,14,15-heptadeoxy-12-methyl-15-phenyl-, 11-acetate 5-octanoate, (7S,11ξ,12ξ,14E)- | [Molecular Formula]
C34H46O14 | [MOL File]
155179-14-9.mol | [Molecular Weight]
678.72 |
| Hazard Information | Back Directory | [Uses]
Zaragozic acid D is a squalene synthase inhibitor. Zaragozic acid D also is a farnesyl-protein transferase (FPTase) inhibitor with an IC50 value of 100 nM for bovine FPTase[1][2]. | [References]
[1] Leeyuan Huang, et al. New fungal metabolites as potential antihypercholesterolemics and anticancer agents. Canadian Journal of Botany, 1995, 73(S1): 898-906.
[2] Dufresne C, et al. Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase. J Nat Prod. 1993 Nov;56(11):1923-9. DOI:10.1021/np50101a009 |
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