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JG26 is an ADAM17 inhibitor. JG26 also inhibits AngII-induced EGFR transactivation and ERK activation in cultured vascular smooth muscle cells (VSMCs). | [Uses]
JG26 is an ADAM17 inhibitor, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively[1]. | [IC 50]
ADAM17: 1.9 nM (IC50); MMP-12: 9.4 nM (IC50); ADAM8: 12 nM (IC50); ADAM10: 150 nM (IC50); MMP-8: 240 nM (IC50); MMP-9: 1630 nM (IC50); MMP14: 19500 nM (IC50); MMP-9: >500000 nM (IC50) | [References]
[1] Doretta Cuffaro, et al. Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors. ACS Med Chem Lett. 2021 Oct 8;12(11):1787-1793. DOI:10.1021/acsmedchemlett.1c00411 |
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