ChemicalBook--->CAS DataBase List--->146669-29-6

146669-29-6

146669-29-6 Structure

146669-29-6 Structure
IdentificationMore
[Name]

(RS)-MCPG
[CAS]

146669-29-6
[Synonyms]

(+/-)-ALPHA-METHYL-(4-CARBOXYPHENYL)GLYCINE
[+/-]-MCPG
(RS)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
(RS)-A-METHYL-4-CARBOXYPHENYLGLYCINE
(RS)-MCPG
(+/-)MCPG
(+/-)-A-METHYL-(4-CARBOXYPHENYL)GLYCINE
(+-)-A-METHYL-4-CARBOXYPHENYLGLYCINE MET ABOTROPIC GLUTAMAT
[Molecular Formula]

C10H11NO4
[MDL Number]

MFCD00210205
[Molecular Weight]

209.2
[MOL File]

146669-29-6.mol
Chemical PropertiesBack Directory
[Boiling point ]

425.3±40.0 °C(Predicted)
[density ]

1.390±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Room temperature
[solubility ]

DMSO : 6 mg/mL (28.68 mM; Need ultrasonic and warming)
[form ]

Powder
[pka]

1.76±0.10(Predicted)
[color ]

White
[InChI]

1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)
[InChIKey]

DNCAZYRLRMTVSF-UHFFFAOYSA-N
[SMILES]

CC(N)(C(O)=O)c1ccc(cc1)C(O)=O
[CAS DataBase Reference]

146669-29-6(CAS DataBase Reference)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
[WGK Germany ]

3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.
[Biological Activity]

Non-selective group I/group II metabotropic glutamate receptor antagonist. See (S)-isomer ((S)-a-Methyl-4-carboxyphenylglycine ).
[in vivo]

(RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons[1].
Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent[2].

[IC 50]

mGluR
[storage]

Room temperature
Spectrum DetailBack Directory
[Spectrum Detail]

(RS)-MCPG(146669-29-6)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

146669-29-6(sigmaaldrich)
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