146670-40-8

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146670-40-8 Structure

Identification	Back Directory
[Name] SR 11237
[CAS] 146670-40-8
[Synonyms] BMS649 SR 11237 BMS 188649 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoicacid 4-(2-(5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dioxolan-2-yl)benzoic acid Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-
[Molecular Formula] C24H28O4
[MDL Number] MFCD00864137
[MOL File] 146670-40-8.mol
[Molecular Weight] 380.48

Chemical Properties	Back Directory
[storage temp. ] Store at -20°C
[solubility ] DMSO: >28mg/mL (warmed)
[form ] powder
[color ] white to off-white
[InChI] 1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26)
[InChIKey] ZZUKALQMHNSWTK-UHFFFAOYSA-N
[SMILES] CC1(C)CCC(C)(C)c2cc(ccc12)C3(OCCO3)c4ccc(cc4)C(O)=O

Safety Data	Back Directory
[WGK Germany ] 3
[Storage Class] 11 - Combustible Solids

[Uses]

SR 11237 is a pan RXR agonist with without RAR activity. It is used in treatment of neurodegenerative diseases.

[Biological Activity]

Pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.

[in vivo]

SR11237 (BMS-649) (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate^[2].

Animal Model:	Sprague-Dawley rats^[2]
Dosage:	25 mg/kg
Administration:	I.p.; daily from post-natal days 5 to 15
Result:	Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis.

[storage]

Store at -20°C

Spectrum Detail	Back Directory
[Spectrum Detail] SR 11237(146670-40-8)¹HNMR

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