| Identification | Back Directory | [Name]
QL47 | [CAS]
1469988-75-7 | [Synonyms]
QL47
QL47,QL-47
BTK Inhibitor
Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[2,3-dihydro-1-(1-oxo-2-propen-1-yl)-1H-indol-6-yl]-9-(1-methyl-1H-pyrazol-4-yl)- | [Molecular Formula]
C27H21N5O2 | [MOL File]
1469988-75-7.mol | [Molecular Weight]
447.49 |
| Chemical Properties | Back Directory | [Boiling point ]
706.2±60.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : < 1 mg/mL (insoluble or slightly soluble) | [form ]
Powder | [pka]
4?+-.0.20(Predicted) | [color ]
Light yellow to yellow | [InChI]
1S/C27H21N5O2/c1-3-25(33)31-11-10-17-4-7-21(13-24(17)31)32-26(34)9-6-19-14-28-23-8-5-18(12-22(23)27(19)32)20-15-29-30(2)16-20/h3-9,12-16H,1,10-11H2,2H3 | [InChIKey]
RTRNJQOBEOISFQ-UHFFFAOYSA-N | [SMILES]
[n]1(ncc(c1)c2cc3c4[n]([c](ccc4cnc3cc2)=O)c5cc6c(cc5)CCN6C(=O)C=C)C |
| Hazard Information | Back Directory | [Uses]
QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC50 of 7 nM[1][2][3]. | [Definition]
ChEBI: 9-(1-methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone is a naphthyridine derivative. | [Biological Activity]
Cell permeable: yes''Primary Target
BMX & BTK''Reversible: no | [References]
[1] Liang Y, et al. Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent. ACS Med Chem Lett. 2017;8(3):344-349. Published 2017 Feb 3. DOI:10.1021/acsmedchemlett.7b00008
[2] de Wispelaere M, et al. A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation. J Biol Chem. 2020;295(6):1694-1703. DOI:10.1074/jbc.RA119.011132
[3] Wu H, et al. Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma. ACS Chem Biol. 2014;9(5):1086-1091. DOI:10.1021/cb4008524 |
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SPIRO PHARMA
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| Tel: |
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www.spiropharma.com.cn |
| Company Name: |
Musechem
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+1-800-259-7612 |
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www.musechem.com |
| Company Name: |
InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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