| Identification | Back Directory | [Name]
L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl- | [CAS]
147732-56-7 | [Synonyms]
Pal-AHK
Pal-GHK-OH
Collaxyl II
Palmitoyl-GHK
Pal-GHK, >=95%
Pal-Tripeptide-1
Palm-Gly-His-Lys
Peptides PAL-Ghk
PAL-GLY-HIS-LYS-OH
Palmiltoyl Tripepti
Pal-GHK/Matrixyl 3000
PALMITOYL TRIPEPTIDE-1
PAL-GHK / palmitoyl-GHK
PalMitoyl Tripeptide-1、3
Palmitoyl Tetrapeptide-1
Pal-GHK | Pal-Gly-His-Lys
Palmitoyl Tripeptide-1Pal-AHK
Palmitoyl Tripeptide-1/Pal-GHK
Pal-GHK(PalMitoyl Tripeptide-1)
Cosmetic peptide powder/Pal-AHK
PAL-GHK (Palmitoyl-Oligopeptide)
Palmiltoyl Tripeptide-1 (Pal-GHK)
Palmitoyl Tripeptide-1, Bio-bustyl
Material Pure Palmitoyl Tripeptide-1
N-Palmitoylglycyl-L-histidyl-L-lysine
Peptide Palmitoyl Tripeptide-1 PAL-GHK
N-(1-Oxohexadecyl)glycyl-L-histidyl-L-lysine
N2-[(N-Palmitoylglycyl)-L-histidyl]-L-lysine
Palmitoyl Tripeptide-1、Palmitoyl Oligopeptide
N-1(1-oxohexadecyl-glycyl-L-histidyl-L-Lysine
Matrixyl 3000 powder / Palmitoyl Tripeptide-1
L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-
Palmitoyl Tripeptide-1 / Pal-GHK/Matrixyl 3000
Matrixyl 3000 / Pal-GHK/ Palmitoyl Tripeptide-1
Cosmetic Raw Material Pure Palmitoyl Tripeptide-1
Collaxyl II / Palmitoyl tripeptide-1, Biopeptide CL
Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7
N2-[N-[N-(1-oxohexadecyl)glycyl]-L-histidyl]-L-lysine
Cosmetic Peptides Palmitoyl Tripeptide-1 Anti-Wrinkle
N-1(1-oxohexadecyl-glycyl-L-histidyl-L-Lysine USP/EP/BP
Peptide Palmitoyl Tripeptide-1 (PAL-GHK / palmitoyl-GHK)
China biggest manufacturer, Palmitoyl Tripeptide,147732-56-7
Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7 USP/EP/BP
Palmitoyl Tripeptide-3 (Pal-AHK)Palmitoyl Tripeptide-3 (Pal-AHK)
Palmitoyl Tripeptide-1 (PalGHK)Palmitoyl Tripeptide-1 (PalGHK)
superior quality N-1(1-oxohexadecyl-glycyl-L-histidyl-L-Lysine CAS 147732-56-7
(S)-2-((S)-3-(1H-Imidazol-5-yl)-2-(2-palmitamidoacetamido)propanamido)-6-aminohexanoic acid | [EINECS(EC#)]
-0 | [Molecular Formula]
C30H54N6O5 | [MDL Number]
MFCD18251733 | [MOL File]
147732-56-7.mol | [Molecular Weight]
578.79 |
| Chemical Properties | Back Directory | [Boiling point ]
913.0±65.0 °C(Predicted) | [density ]
1.105 | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 30 mg/ml | [form ]
A solid | [pka]
3.16±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Pal-Gly-His-Lys | [Cosmetics Ingredients Functions]
SKIN CONDITIONING | [Cosmetic Ingredient Review (CIR)]
Palmitoyl Tripeptide-1 (147732-56-7) | [InChIKey]
BYUQATUKPXLFLZ-UIOOFZCWSA-N | [SMILES]
C(O)(=O)[C@H](CCCCN)NC(=O)[C@H](CC1N=CNC=1)NC(=O)CNC(=O)CCCCCCCCCCCCCCC |
| Hazard Information | Back Directory | [Description]
A peptide is two or more amino acids joined together and is the building block of protein. Peptides fall into three main categories: signal peptides, carrier peptides, and those that inhibit nerve signals. Signal peptides, like palmitoyl tripeptide-1, act as messengers to cells, which trigger collagen synthesis, which then increases skin firmness.Palmitoyl tripeptide-1 is a small three amino acid signal peptide with the amino sequence of glycine-histidine-lysine (GHK). GHK is attached to palmitic acid (a fatty acid) to increase its skin penetration and oil solubility. | [Uses]
Palmitoyl Tripeptide-1, has shown to have effects on on collagen, fibronectin, hyaluronic acid synthesis in human dermal fibroblasts, and thus can be used in preparation of antiaging cosmetic creams. | [Application]
Palmitoyl Tripeptide-1 (Pal-GHK, SpecPed? PT1P) is useful in anti-aging products and wrinkle treatment products such as gels, serums, lotions and creams. Acting as messengers of cutaneous restructuration and repair, this peptide works synergistically to restore and maintain the skin's youthful appearance. | [Biological Activity]
Pal-GHK is a form of the extracellular matrix-derived peptide GHK containing palmitic acid , which allows it to penetrate the stratum corneum to the epidermal and dermal skin layers. Pal-GHK (0.5 μM) increases collagen synthesis in human skin fibroblasts in vitro. It reduces collagen degradation ex vivo in patient-derived human skin samples irradiated with UVA light when used at a concentration of 6 ppm. It has been used with the zwitterionic surfactant C12 dodecyldimethylamine oxide (C12DMAO) to study self-assembly of the mixture into aggregates, ribbons, and nanobelts. Pal-GHK has also been used as an internal standard for the quantification of pal-KTTKS in anti-wrinkle creams by LC-MS/MS. | [Clinical Use]
Applying palmitoyl tripeptide-1 directly to your skin tells the cells to make more collagen, stimulating new collagen production. It requires at least one month or more to begin to see visible changes from new collagen with maximum results visible after 3 to 4 months. Erin Gilbert, MD, FAAD, Ph.D., and board-certified dermatologist and neuroscientist, continues: "Peptides can be included in serums, moisturizers, and masks," Gilbert explains. "They are also included in some topical serums used after micro-needling or superficial laser procedures to increase the penetration of the peptide and help the skin recover from the procedure." | [Safety]
The CIR Expert Panel concluded that peptides, such as palmitoyl tripeptide-1, are safe in cosmetics and self-care products. Environmental Working Group (EWG) currently scores palmitoyl tripeptide-1 as “1” or “low hazard.”Overall, peptides, such as palmitoyl tripeptide-1, mimic what already exists in the human body and research on peptides’ impact on the skin shows limited to no skin irritation. In terms of toxicity caused by peptides, there is no published research to document any known toxicity. | [References]
[1] LINTNER P. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product[J]. International Journal of Cosmetic Science, 2001, 22 3: 207-218. DOI: 10.1046/j.1467-2494.2000.00010.x
[2] HAN ZHANG . Modulating self-assembly behavior of a salt-free peptide amphiphile (PA) and zwitterionic surfactant mixed system[J]. Journal of Colloid and Interface Science, 2016, 467: Pages 43-50. DOI: 10.1016/j.jcis.2015.12.005
[3] VALERIA CASTELLETTO. Self-Assembly of Palmitoyl Lipopeptides Used in Skin Care Products[J]. Langmuir, 2013, 29 29: 9149-9155. DOI: 10.1021/la401771j
[4] RALUCA-IOANA CHIRITA . Development of a LC–MS/MS method to monitor palmitoyl peptides content in anti-wrinkle cosmetics[J]. Analytica Chimica Acta, 2009, 641 1: Pages 95-100. DOI: 10.1016/j.aca.2009.03.015 |
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MarsLab Gold
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17549219037 17549219037 |
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marslabbio.manus.space |
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AF Biochem Co., Ltd.
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+86-028-60911900 13540204019 |
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www.afbiochem.com |
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T&W GROUP
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www.trustwe.com/ |
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