| Identification | Back Directory | [Name]
UDM-001651 | [CAS]
1477497-01-0 | [Synonyms]
UDM-001651
UDM001651,UDM 001651
Imidazo[2,1-b]-1,3,4-thiadiazole, 2-methoxy-6-[6-methoxy-4-[[3-(phenylmethoxy)phenyl]methoxy]-2-benzofuranyl]- | [Molecular Formula]
C28H23N3O5S | [MDL Number]
MFCD32174291 | [MOL File]
1477497-01-0.mol | [Molecular Weight]
513.56 |
| Hazard Information | Back Directory | [Uses]
UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM). UDM-001651 shows antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP)[1]. | [IC 50]
PAR4 | [References]
[1] Miller MM, et al. Discovery of Potent Protease-Activated Receptor 4 Antagonists with in vivo Antithrombotic Efficacy. J Med Chem. 2019 Jun 27. DOI:10.1021/acs.jmedchem.9b00186 |
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