| Identification | Back Directory | [Name]
1-(5-chloro-2-methylphenyl)-3-(2-methylpropyl)thi ourea | [CAS]
147751-31-3 | [Synonyms]
HDL376
HDL-376
HDL 376
1-(5-chloro-2-methylphenyl)-3-(2-methylpropyl)thi ourea
Thiourea, N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)- | [Molecular Formula]
C12H17ClN2S | [MDL Number]
MFCD00917923 | [MOL File]
147751-31-3.mol | [Molecular Weight]
256.79 |
| Chemical Properties | Back Directory | [Boiling point ]
332.2±52.0 °C(Predicted) | [density ]
1.181±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.20±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HDL376 is a scavenger receptor class B type I (SR-BI) inhibitor. HDL376 directly inhibits SR-BI-mediated lipid transport in cells and in liposomes reconstituted with purified SR-BI (IC50 = 0.22 μM). HDL376 can be used for the research of atherosclerotic coronary artery disease[1]. | [References]
[1] Nieland TJ, et al. Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI. J Lipid Res. 2007 Aug;48(8):1832-45. DOI:10.1194/jlr.M700209-JLR200 |
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