| Identification | Back Directory | [Name]
Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- | [CAS]
1604821-43-3 | [Synonyms]
Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- | [Molecular Formula]
C23H23N3O5S | [MOL File]
1604821-43-3.mol | [Molecular Weight]
453.51 |
| Chemical Properties | Back Directory | [density ]
1.339±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 5mg/mL | [form ]
solid | [pka]
6.84±0.50(Predicted) | [color ]
light yellow |
| Hazard Information | Back Directory | [Uses]
A cell-permeable, non-toxic, indolinyl-thiazole based compound that acts as a highly potent, reversible inhibitor of lipid uptake via scavenger receptor class B type I (SR-BI; IC50 = 6 nM). Shown to block the uptake of [3H] labeled cholesteryl oleate ester ([3H]CE) from [3H]CE-HDL (IC50 = 7 nM). Exhibits high selectivity when tested against a panel of 67 different receptors and secondary targets (at 10 µM). Displays excellent stability in human plasma (99% remaining after 5 h, with 94% plasma protein bound) and mouse liver microsomes (75% remaining after 1 h).
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. | [Biological Activity]
Cell permeable: yes''Primary Target
scavenger receptor class B type I''Reversible: yes |
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| Company Name: |
Merck KGaA
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| Telephone: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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