| Identification | Back Directory | [Name]
ITSFEEAKGLDRINERMPPRRDAMP | [CAS]
148067-21-4 | [Synonyms]
CN412
ITSFEEAKGLDRINERMPPRRDAMP
AUTOINHIBITORY PEPTIDE 457-482
CALCINEURIN AUTOINHIBITORY PEPTIDE
CALCINEURIN AUTOINHIBITORY FRAGMENT
Calcineurin autoinhibitory peptide, ≥90% (HPLC)
CalcineurinAutoinhibitoryPeptide,CalcineurinAutoinhibitoryPeptid
ILE-THR-SER-PHE-GLU-GLU-ALA-LYS-GLY-LEU-ASP-ARG-ILE-ASN-GLU-ARG-MET-PRO-PRO-ARG-ARG-ASP-ALA-MET-PRO
H-ILE-THR-SER-PHE-GLU-GLU-ALA-LYS-GLY-LEU-ASP-ARG-ILE-ASN-GLU-ARG-MET-PRO-PRO-ARG-ARG-ASP-ALA-MET-PRO-OH
ILE-THR-SER-PHE-GLU-GLU-ALA-LYS-GLY-LEU-ASP-ARG-ILE-ASN-GLU-ARG-MET-PRO-PRO-ARG-ARG-ASP-ALA-MET-PRO: ITSFEEAKGLDRINERMPPRRDAMP
L-Proline,L-isoleucyl-L-threonyl-L-seryl-L-phenylalanyl-L-a-glutamyl-L-a-glutamyl-L-alanyl-L-lysylglycyl-L-leucyl-L-a-aspartyl-L-arginyl-L-isoleucyl-L-asparaginyl-L-a-glutamyl-L-arginyl-L-methionyl-L-prolyl-L-prolyl-L-arginyl-L-arginyl-L-a-aspartyl-L-alan
L-Proline, L-isoleucyl-L-threonyl-L-seryl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-lysylglycyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucyl-L-asparaginyl-L-α-glutamyl-L-arginyl-L-methionyl-L-prolyl-L-prolyl-L-arginyl-L-arginyl-L-α-aspartyl-L-alanyl-L-methionyl- | [Molecular Formula]
C124H205N39O39S2 | [MDL Number]
MFCD00214597 | [MOL File]
148067-21-4.mol | [Molecular Weight]
2930.32 |
| Hazard Information | Back Directory | [Uses]
Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death[1][2]. | [storage]
Desiccate at -20°C | [References]
[1] Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7. PMID:2153670
[2] Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51. DOI:10.1046/j.1471-4159.2003.02098.x |
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