| Identification | Back Directory | [Name]
CALP2 | [CAS]
261969-04-4 | [Synonyms]
CALP2
L-Phenylalanine, L-valyl-L-lysyl-L-phenylalanylglycyl-L-valylglycyl-L-phenylalanyl-L-lysyl-L-valyl-L-methionyl-L-valyl- (9CI) | [Molecular Formula]
C68H104N14O13S | [MDL Number]
MFCD08686764 | [MOL File]
261969-04-4.mol | [Molecular Weight]
1357.7 |
| Chemical Properties | Back Directory | [Boiling point ]
1602.4±65.0 °C(Predicted) | [density ]
1.205±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [solubility ]
Soluble to 0.50 mg/ml in 10% ethanol / water | [form ]
Powder | [pka]
3.50±0.10(Predicted) | [Sequence]
Val-Lys-Phe-Gly-Val-Gly-Phe-Lys-Val-Met-Val-Phe |
| Hazard Information | Back Directory | [Uses]
CALP2 is a calmodulin (CaM) antagonist ( (Kd of 7.9 μM)) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages[1][2][3][4]. | [References]
[1] R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166(2):861-7. DOI:10.4049/jimmunol.166.2.861
[2] R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15(10):1831-3. DOI:10.1096/fj.01-0018fje
[3] Robert Ten Broeke, et al. Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab Invest. 2004 Jan;84(1):29-40. DOI:10.1038/sj.labinvest.3700002
[4] M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275(4):2676-85. DOI:10.1074/jbc.275.4.2676 |
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