| Identification | More | [Name]
L(+)-Homoarginine hydrochloride | [CAS]
1483-01-8 | [Synonyms]
2-AMINO-6-GUANIDINO-HEXANOIC ACID, HCL
2-AMINO-6-GUANIDINOHEXANOIC ACID HYDROCHLORIDE
H-HAR-OH HCL
H-HOMOARG-OH HCL
H-HOMOARG-OH HYDROCHLORIDE
H-L-HOARG-OH HCL
HOMOARGININE HYDROCHLORIDE
L(+)-HOMOARGININE HCL
L-HOMOARGININE HCL
L(+)-HOMOARGININE HYDROCHLORIDE
L-HOMOARGININE HYDROCHLORIDE
L-HOMOARGININE MONOHYDROCHLORIDE
L-(S)-2-AMINO-6-GUANIDINOHEXANOIC ACID HYDROCHLORIDE
(S)-2-AMINO-6-GUANIDINOHEXANOIC ACID HYDROCHLORIDE
N6-(AMINOIMINOMETHYL)-L-LYSINE
L-HomoarginineHydrochloride>99%
H-L-HArg-OH*HCl
L-Homoarginine hydrochloride, (S)-2-Amino-6-guanidinohexanoic acid hydrochloride
L-Homoarginine hydrochloride, 98+%
2-Amino-6-(diaminomethylideneamino)hexanoic acid hydrochloride | [EINECS(EC#)]
216-045-6 | [Molecular Formula]
C7H17ClN4O2 | [MDL Number]
MFCD00012622 | [Molecular Weight]
224.69 | [MOL File]
1483-01-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White Powder | [Melting point ]
213-215 °C(lit.) | [alpha ]
18 º (c=1, 1N HCl) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
H2O: 50 mg/mL, clear to slightly hazy, faintly yellow
| [form ]
Granular Powder | [color ]
White | [Water Solubility ]
Soluble in water(50 mg/mL). | [Usage]
An inhibitor of alkaline phosphatase isoenzymes | [BRN ]
4016621 | [Stability:]
Moisture Sensitive | [Major Application]
peptide synthesis | [InChI]
InChI=1/C7H16N4O2.ClH/c8-5(6(12)13)3-1-2-4-11-7(9)10;/h5H,1-4,8H2,(H,12,13)(H4,9,10,11);1H/t5-;/s3 | [InChIKey]
YMKBVNVCKUYUDM-USHJBNIQNA-N | [SMILES]
C(CCCNC(=N)N)[C@H](N)C(=O)O.Cl |&1:8,r| | [CAS DataBase Reference]
1483-01-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [HS Code ]
29252900 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Description]
L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases.1 This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [3H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells.2 Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.3 | [Chemical Properties]
White Powder | [Uses]
An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000). | [Uses]
An inhibitor of alkaline phosphatase isoenzymes. It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements. | [Biochem/physiol Actions]
Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. | [IC 50]
Human Endogenous Metabolite | [References]
[1] CHI-WEI LIN W F. L-Homoarginine. An organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases.[J]. The Journal of Biological Chemistry, 1972, 16 1: 3082-3087. DOI: 10.1016/s0021-9258(19)45215-0
[2] Y KIKUCHI K K I Kizawa. [Inhibitory effect of L-homoarginine on murine osteosarcoma cell proliferation].[J]. Japanese Journal of Cancer and Chemotherapy, 1982, 9 5: 888-897.
[3] T. HIRA H. H S Ohyama. l-Homoarginine suppresses exocrine pancreas in rats[J]. Amino Acids, 2003, 24 4: 389-396. DOI: 10.1007/s00726-002-0344-2 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|