ChemicalBook--->CAS DataBase List--->14899-36-6

14899-36-6

14899-36-6 Structure

14899-36-6 Structure
IdentificationBack Directory
[Name]

Dexamethasone palmitate
[CAS]

14899-36-6
[Synonyms]

D01615
Lipotalon
Limethason
Limethasone
Limethason (tn)
DXM-21-palmitate
DEXAMETHASOME PALMITATE
Dexamethasone palmitate
Dexamethasone-21-palmitate
Dexamethasone palmitate (jan)
9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-palmitate
21-(Palmitoyloxy)-9α-fluoro-11β,17α-dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-palmitate (6CI, 8CI)
(11β,16α)-9-Fluoro-11,17-dihydroxy-16-Methyl-21-[(1-oxohexadecyl)oxy]pregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(1-oxohexadecyl)oxy]-, (11β,16α)-
Palmitic acid, 21-ester with 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione (8CI)
[Molecular Formula]

C38H59FO6
[MOL File]

14899-36-6.mol
[Molecular Weight]

630.87
Chemical PropertiesBack Directory
[Melting point ]

60-65 °C
[Boiling point ]

710.1±60.0 °C(Predicted)
[density ]

1.12
[storage temp. ]

Hygroscopic, -20?C Freezer, Under Inert Atmosphere
[solubility ]

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

11.99±0.70(Predicted)
[color ]

White to Pale Yellow
[Stability:]

Hygroscopic
Hazard InformationBack Directory
[Chemical Properties]

Colourless Thick Oil
[Uses]

A corticosteroid prodrug for the treatment of eye disorders.
[Description]

Dexamethasone palmitate (DXP) is a prodrug of dexamethasone,which is a steroidal antinflammatory drug that is used to treat certain pain and inflammatory conditions such as asthma and rheumatoid arthritis. This prodrug was prepared to increase the distribution of the parent drug, dexamethasone, in the lungs for local drug delivery and to prevent its entry into the systemic circulation. This prodrug was developed as a powder formulation that needs to be administered via the pulmonary route so that it can easily reach into the lungs and show its effect locally.Normal delivery of dexamethasone enters systemic circulation very easily but this palmitate prodrug cannot easily enter into the systemic circula-tion. Within the lungs, the prodrug is acted upon by esterase enzyme that brings about hydrolysis,leading to the release of parent drug and increases the distribution of parentdrug inside the lungs (N'Guessan et al.,2018).
[Definition]

ChEBI: Dexamethasone palmitate is an organic molecular entity.
[Biochem/physiol Actions]

Dexamethasone Palmitate is a lipophilic prodrug of a potent corticosteroid dexamethasone that is quickly taking up by macrophages via phagocytosis. Dexamethasone Palmitate inhibits function and migration of leukocytes and tissue macrophages.
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