| Identification | Back Directory | [Name]
6-hydroxydexamethasone | [CAS]
55879-47-5 | [Synonyms]
6-hydroxydexamethasone
6β-hydroxy Dexamethasone
Dexamethasone Impurity 12
Dexamethasone 6β-Hydroxy Impurity
Dexamethasone 6beta-Hydroxy Impurity
6-Hydroxydexamethasone Solution, 100ppm
(6R,8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one | [Molecular Formula]
C22H29FO6 | [MOL File]
55879-47-5.mol | [Molecular Weight]
408.46 |
| Chemical Properties | Back Directory | [Melting point ]
259-262°C | [Boiling point ]
613.2±55.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Dioxane (Very Slightly, Sonicated), Methanol (Slightly) | [form ]
Solid | [pka]
12.06±0.70(Predicted) | [color ]
White to Light Yellow |
| Hazard Information | Back Directory | [Description]
6β-hydroxy Dexamethasone is a metabolite of dexamethasone (Item Nos. 11015 | 20340) that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans. The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats. | [Chemical Properties]
Off-White Solid | [Uses]
The hydrophilic metabolite of Dexamethasone (D298800). |
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| Company Name: |
BOC Sciences
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16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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