| Identification | Back Directory | [Name]
CGP-53153 | [CAS]
149281-19-6 | [Synonyms]
CGP-53153
1H-Indeno[5,4-f]quinoline-7-carboxamide, N-(1-cyano-1-methylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)- | [Molecular Formula]
C23H33N3O2 | [MDL Number]
MFCD00920299 | [MOL File]
149281-19-6.mol | [Molecular Weight]
383.53 |
| Chemical Properties | Back Directory | [Boiling point ]
627.0±55.0 °C(Predicted) | [density ]
1.118±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
12.88±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
CGP-53153 is a steroidal inhibitor of 5 alpha reductase with IC50s of 36 and 262 nM in rat and human prostatic tissue, respectively. | [in vivo]
CGP-53153 can significantly reduce T-propionate-mediated prostate growth at oral doses of 0.01 mg/kg. CGP-53153 significantly reduces prostate weight at 3 and 10 mg/kg by 31% and 37%, respectively. Treatment for 12 weeks with both CGP-53153 reduces prostate volume by more than 70% in individual dogs. Neither body weight nor the weight of any organ tested is affected by CGP-53153[1]. | [storage]
Store at -20°C | [References]
[1] H?usler A, et al. CGP-53153: a new potent inhibitor of 5alpha-reductase. J Steroid Biochem Mol Biol. 1996 Feb;57(3-4):187-95. DOI:10.1016/0960-0760(95)00260-x |
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BOC Sciences
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https://www.bocsci.com |
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MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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