| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Uses]
U 92016A is a selective SR-1A agonist. | [Biological Activity]
Selective 5-HT 1A receptor agonist that displays high intrinsic activity (K i values are 0.4, 7.7 and 36 nM for 5-HT 1A , 5-HT 1D and D 2 receptors respectively and > 1000 nM for 5-HT 2 , D 1 , α 1 and α 2 receptors). Produces hypothermia, hypotension and 5-HT behavioral syndrome following p.o. administration. | [in vivo]
U92016A (U-92016A) potently decreases rectal temperature in mice. U92016A also elicits the 5-HT-mediated syndrome in rats and results in a dose-related decrease in 5-hydroxytryptophan accumulation. U92016A also decreases arterial blood pressure in spontaneously hypertensive rats and inhibits sympathetic nerve activity in cats. U92016A displays excellent potency and a long duration of action. U92016A also inhibits the firing of dorsal raphe 5-HT neurons and is active in two social interaction assays. The p.o. bioavailability of U92016A is 45%[2]. | [IC 50]
5-HT1A Receptor: 0.2 nM (Ki) | [storage]
Store at -20°C |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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