| Identification | Back Directory | [Name]
Telomerase-IN-3 | [CAS]
150096-77-8 | [Synonyms]
Telomerase-IN-3
Benzamide, 2-amino-N-[[[4-[(5-chloro-2-pyrimidinyl)oxy]-3-methylphenyl]amino]carbonyl]- | [Molecular Formula]
C19H16ClN5O3 | [MDL Number]
MFCD04034548 | [MOL File]
150096-77-8.mol | [Molecular Weight]
397.82 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 25 mg/mL (62.84 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [color ]
Off-white to light yellow | [InChI]
1S/C19H16ClN5O3/c1-11-8-13(6-7-16(11)28-19-22-9-12(20)10-23-19)24-18(27)25-17(26)14-4-2-3-5-15(14)21/h2-10H,21H2,1H3,(H2,24,25,26,27) | [InChIKey]
NLVSCQFSPVSAOF-UHFFFAOYSA-N | [SMILES]
NC1=CC=CC=C1C(NC(NC2=CC(C)=C(C=C2)OC3=NC=C(C=N3)Cl)=O)=O |
| Hazard Information | Back Directory | [Uses]
Telomerase-IN-3 is a telomerase inhibitor, which directly targets hTERT promoter activity. hTERT is the key component for maintenance of telomerase activity[1]. | [Biological Activity]
RG1534 is an inhibitor of hTERT promoter activity th at selectively targets G-hairpin stem loop of the human telomerase reverse transcriptase gene (hTERT) th at downregulates hTERT expression. RG1534 induces mitochondrial defectsoxidative stressDNA damage and apoptosis in cancer cell while sparing normal cells | [storage]
Store at -20°C | [References]
[1] Laurence Hurley, et al. hTERT MODULATORS AND METHODS OF USE. WO2017095969A1. |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
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www.medchemexpress.com |
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