| Identification | Back Directory | [Name]
L-701,252 | [CAS]
151057-13-5 | [Synonyms]
L-701,252
151057-13-5
7-CHLORO-3-(CYCLOPROPYL-CARBONYL)-4-HYDROXY-2(1H)-QUINOLINE
7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINONE
7-Chloro-3-(cyclopropanecarbonyl)-4-hydroxyquinolin-2(1H)-one
2(1H)-Quinolinone, 7-chloro-3-(cyclopropylcarbonyl)-4-hydroxy-
7-chloro-3-[cyclopropyl(oxo)methyl]-2-hydroxy-1H-quinolin-4-one
7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINE[L-701, 252] | [Molecular Formula]
C13H10ClNO3 | [MDL Number]
MFCD00673760 | [MOL File]
151057-13-5.mol | [Molecular Weight]
263.68 |
| Chemical Properties | Back Directory | [Boiling point ]
516.8±50.0 °C(Predicted) | [density ]
1.573±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [solubility ]
Soluble to 50 mM in DMSO | [form ]
White crystalline solid. | [pka]
4.50±1.00(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C13H10ClNO3/c14-7-3-4-8-9(5-7)15-13(18)10(12(8)17)11(16)6-1-2-6/h3-6H,1-2H2,(H2,15,17,18) | [InChIKey]
MXEFWCFPCLDOOG-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=CC(Cl)=C2)C(O)=C(C(C2CC2)=O)C1=O |
| Hazard Information | Back Directory | [Uses]
L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1]. | [Definition]
ChEBI:7-chloro-3-[cyclopropyl(oxo)methyl]-4-hydroxy-1H-quinolin-2-one is a quinolone and a hydroxyquinoline. | [Biological Activity]
An antagonist at the glycine-NMDA site (IC 50 = 420 nM). Also a potent systemic anticonvulsant. | [in vivo]
L-701252 (50 mg/kg; i.p.) provides a small non-significant protection[1]. | Animal Model: | 3-Months Male Mongolian gerbils (60 g)[1] | | Dosage: | 50 mg/kg | | Administration: | i.p. | | Result: | Provided a small non-significant protection. |
| [IC 50]
NMDA Receptor | [storage]
Store at -20°C | [References]
[1] Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154. DOI:10.1016/s0165-6147(00)01451-6
[2] Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242. DOI:10.1016/s0006-8993(96)00779-2 |
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