| Identification | Back Directory | [Name]
Licostinel | [CAS]
153504-81-5 | [Synonyms]
CGP 63446
CGP-63446
Licostinel
6,7-dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione
2,3-Quinoxalinedione, 6,7-dichloro-1,4-dihydro-5-nitro-
6,7-dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione(WXC05743) | [Molecular Formula]
C8H3Cl2N3O4 | [MDL Number]
MFCD00672687 | [MOL File]
153504-81-5.mol | [Molecular Weight]
276.03 |
| Hazard Information | Back Directory | [Uses]
5-Nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione is a strong and selective NMDA receptor glycine site antagonist. CNS therapeutic agents. | [Uses]
NMDA antagonist. | [in vivo]
| Animal Model: | The permanent model of middle cerebral artery occlusion in fisher 344 rats and CD-1 mice.
The transient model of focal ischemia in Wistar and Sprague –Dawley rats
[2 | | Dosage: | 5 mg/kg bolus 3.5 mg/kg/h for 6h, 10 mg/kg bolus 7.0 mg/kg/h for 6h | | Administration: | A single intravenous injection bolus continuous infusion | | Result: | Decreased infarct size. |
| Animal Model: | Male Sprague-Dawley rats [3] | | Dosage: | 20, 40, 80 mg/kg for intraperitoneal injection (i.p.) bolus 7 mg/kg/h , 30mins | | Administration: | Intravenous injection (i.v.) bolus continuous infusion | | Result: | Reduced the rate of spreading depression and EEG activity in the rat brain in a dose-dependent manner. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
|