| Identification | Back Directory | [Name]
Pramlintide | [CAS]
151126-32-8 | [Synonyms]
CL062
Triproamylin
Lys-c[Cys-Asn-Thr-Ala-Thr-Cys]-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu
-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly
-Ser-Asn-Thr-Tyr-NH2 | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C171H267N51O53S2.C2H4O2.H2O | [MDL Number]
MFCD09837708 | [MOL File]
151126-32-8.mol | [Molecular Weight]
4027.49 |
| Chemical Properties | Back Directory | [solubility ]
soluble in Water | [form ]
Solid | [color ]
White | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bridge:Cys2-Cys7) | [InChIKey]
FVNLNEGMCMHEBF-CLRARMPYNA-N |
| Hazard Information | Back Directory | [Uses]
Antidiabetic. | [Enzyme inhibitor]
This 37-residue pancreatic β-cell hormone (MW = 3.9 kDa; Sequence:
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY), also called
Islet Amyloid Polypeptide (IAPP), is co-secreted with insulin and plays a
role in glycemic regulation by retarding gastric emptying and promoting
satiety. Amylin helps to prevent post-prandial spikes in blood glucose.
Amylin potently inhibits (EC50 = 18 pM) amino acid-stimulated glucagon
secretion. (Note: Human amylin is amyloidogenic, whereas the synthetic
hormone known as Pramlintide (MW = 3951.41g; CAS 151126-32-8;
Sequence: KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2;
Tradename: Symlin?) contains three prolyl residues that are found in Rat
Amylin (Sequence: KCNTATCATQRLANFLVRSSNNLGPVLPPTNG
SNTY) and is nonamyloidogenic.) | [storage]
Store at -20°C |
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