| Identification | Back Directory | [Name]
ACETYL-PEPSTATIN | [CAS]
28575-34-0 | [Synonyms]
Aids080613
Aids-080613
Ac-Pepstain
AC-PEPSTATIN
ACETYL-PEPSTATIN
N-Acetyl-Pepstatin
PEPSTATIN, ACETYL-
AC-VAL-VAL-STA-ALA-STA
AC-VAL-VAL-STA-ALA-STA-OH
ACETYL-PEPSTATIN USP/EP/BP
Pepstatin A monoacetate (ester)
Ac-Pepstain/AC-VAL-VAL-STA-ALA-STA
AC-VAL-VAL-(3S,4S)-STA-ALA-(3S,4S)-STA-OH
Acetyl-Pepstatin Ac-Val-Val-Sta-Ala-Sta-OH
N-ACETYL-VAL-VAL(3S,4S)-STA-ALA-(3S,4S)-STA
Acetyl-Pepstatin - CAS 28575-34-0 - Calbiochem
(3S,7S,11S,12S,14S,18S)-11-Acetoxy-14-carbamoyl-3-hydroxy-4,12-diisobutyl-18-isopropyl-7,15,22-trimethyl-6,9,17,20-tetraoxo-5,8,13,19-tetraazatricosan-1-oic acid
(3S,4S)-4-[[(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoic acid | [Molecular Formula]
C31H57N5O9 | [MDL Number]
MFCD00214071 | [MOL File]
28575-34-0.mol | [Molecular Weight]
643.81 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to Off-white | [InChIKey]
WKYBEGDEGRCZNF-AHXZNPHMNA-N | [SMILES]
[C@H](CC(C)C)([C@@H](O)CC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)[C@@H](O)CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)C |&1:0,5,11,16,21,30,37,r| |
| Hazard Information | Back Directory | [Uses]
Acetyl Pepstatin is an HIV-1 protease inhibitor. | [General Description]
An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7). | [Biochem/physiol Actions]
Target Ki: 20 nM at pH 4.7 against HIV-1 proteinase | [in vivo]
Pepstatin (Pepstatin A) has a very low toxicity, with LD50s of 1090 mg/kg, 875 mg/kg, 820 mg/kg and 450 mg/kg for mice, rats, rabbits, and dogs by i.p. route, and > 2000 mg/kg for all species by oral route[1].
Pepstatin (0.5-50 mg/kg, p.o.) suppresses stomach ulceration of the pylorus in ligated Shay rats[1]. | Animal Model: | Pylorus ligated male Wistar rats[1] | | Dosage: | 0.5, 1, 10 and 50 mg/kg | | Administration: | Oral administration, 15 minutes after pyloric ligation | | Result: | Effectively prevented stomach ulceration. |
| [storage]
Store at -20°C |
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