| Chemical Properties | Back Directory | [Boiling point ]
722.0±60.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (295.15 mM; Need ultrasonic) | [form ]
Solid | [pka]
11.97±0.20(Predicted) | [color ]
Brown to gray |
| Hazard Information | Back Directory | [Uses]
UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer.?UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar?Kd?of 13?nM[1]. | [in vivo]
UCB-9260 (150?mg/kg; p.o.;twice daily?for 7 days) shows a significant reduction of the clinical score[1].
?
UCB-9260?(10-300?mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment in adult male Balb/c mice[1]. | Animal Model: | Aged 6-8 weeks adult male Balb/c mice?(?CAIA model)[1] | | Dosage: | 150?mg/kg | | Administration: | p.o.; twice daily for 7days? | | Result: | Showed a significant reduction of the clinical score. |
| [References]
[1] O'Connell J, et al.Small?molecules?that?inhibit?TNF?signalling?by?stabilising?an?asymmetric?form?of the?trimer.Nat Commun.?2019 Dec 19;10(1):5795. DOI:10.1038/s41467-019-13616-1 |
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| Company Name: |
ChemShuttle, Inc.
|
| Tel: |
0510-83588313-811 18800520310 |
| Website: |
www.jiehuapharma.com/ |
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