| Identification | Back Directory | [Name]
2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]- | [CAS]
1519043-97-0 | [Synonyms]
YCWE11
YCW-E11
YCW E11
2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]- | [Molecular Formula]
C25H21Cl2N3O6S2 | [MOL File]
1519043-97-0.mol | [Molecular Weight]
594.49 |
| Hazard Information | Back Directory | [Description]
YCW-E11 is a inhibitor of antiapoptotic Bcl-2 family proteins. | [Uses]
YCW-E11 is a Bcl-2, and Mcl-1 inhibitor with Ki values of 0.83 and 0.33 μM, respectively. YCW-E11 induces cell apoptosis through the mitochondrial pathway and exhibits antitumor activity. YCW-E11 can be utilized in cancer research[1]. | [IC 50]
Bcl-2; Mcl-1 | [References]
[1] Yang C, et al. Development of 3-phenyl-N-(2-(3-phenylureido)ethyl)-thiophene-2-sulfonamide compounds as inhibitors of antiapoptotic Bcl-2 family proteins. ChemMedChem. 2014 Jul;9(7):1436-52. DOI:10.1002/cmdc.201400058 |
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