| Identification | Back Directory | [Name]
benzyloxycarbonylleucyl-leucyl-leucyl-4-methyl-coumaryl-7-amide | [CAS]
152015-61-7 | [Synonyms]
Z-Leu-Leu-Phe-CHO [MG-110]
benzyloxycarbonylleucyl-leucyl-leucyl-4-methyl-coumaryl-7-amide
L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate | [Molecular Formula]
C36H48N4O7 | [MDL Number]
MFCD01074988 | [MOL File]
152015-61-7.mol | [Molecular Weight]
648.79 |
| Chemical Properties | Back Directory | [Boiling point ]
887.7±65.0 °C(Predicted) | [density ]
1.174±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Acetone: soluble; DMF: soluble; DMSO: soluble | [form ]
A solid | [pka]
11.14±0.46(Predicted) | [color ]
Solid lyophilized powder | [Sequence]
Z-Leu-Leu-Leu-AMC |
| Hazard Information | Back Directory | [Uses]
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome[1]. | [storage]
+4°C | [References]
[1] McNaught KS, et al. Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci Lett. 2001 Jan 19;297(3):191-4. DOI:10.1016/s0304-3940(00)01701-8 |
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