| Identification | Back Directory | [Name]
10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)- | [CAS]
2761578-18-9 | [Synonyms]
20S Proteasome activator 1
10H-Phenothiazine-10-propanamide, 2-chloro-N,N-bis(4-fluorophenyl)- | [Molecular Formula]
C27H19ClF2N2OS | [MOL File]
2761578-18-9.mol | [Molecular Weight]
492.97 |
| Chemical Properties | Back Directory | [Boiling point ]
713.8±60.0 °C(Predicted) | [density ]
1.380±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
-1.46±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
20S Proteasome activator 1 is a potent 20S proteasome activator with EC200 values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases[1]. | [References]
[1] Staerz SD, et al. Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies. J Med Chem. 2022 May 12;65(9):6631-6642. DOI:10.1021/acs.jmedchem.1c02158 |
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