| Identification | More | [Name]
4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid | [CAS]
152628-03-0 | [Synonyms]
2-N-PROPYL-4-METHYL-6-CARBOXY-BENZIMIDAZOLE
2-N-PROPYL-4-METHYLBENZIMIDAZOLE-6-CARBOXYLIC ACID
2-PROPYL-4-METHYL-6-CARBOXYL BENZIMIDAZOLE
4-METHYL-2-N-PROPYL-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID
4-METHYL-2-PROPYL-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID
4-METHYL-2-PROPYL-6-CARBOXYL BENZIMIDAZOLE
4-Methyl-2-Propyl-1h-Benzimidazole-6-Carboxyboxylic Acid
1H-BENZIMIDAZOLE-6-CARBOXYLIC-4-METHYL-2-PROPYL
4-Methyl-2-Propyl-1H-Benzimidazole-6-CarboxylicAcid[TelmisartanIntermediates]
2-N-Propyl-4-Methyl-6-Carbony-Benzimidazole
2-PROPYL-4-METHYL-1H-BENZIMIDAZOLE-6-CARBOXYLICACID
1H-Benzimidazole-5-carboxylic acid, 7-methyl-2-propyl,
1H-Benzimidazol-5-carbonsure, 7-methyl-2-propyl-
4-METHYL-2-PROPYL-6-BENZIMIDAZOLECARBOXYLIC ACID
2-n-Propyl-4-Methyl-6-Carboxylate-1H-Benzimidazole
6-Carboxy-4-methyl-2-propylbenzimidazole | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C12H14N2O2 | [MDL Number]
MFCD06656215 | [Molecular Weight]
218.25 | [MOL File]
152628-03-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Light Yellow to Tan Powder | [Melting point ]
300 °C | [Boiling point ]
491.8±25.0 °C(Predicted) | [density ]
1.259±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO, Methanol | [form ]
Powder | [pka]
3.19±0.30(Predicted) | [color ]
Pale Yellow to Tan | [Usage]
A useful synthetic intermediate | [InChIKey]
XWAJTVCEILFDGU-UHFFFAOYSA-N | [CAS DataBase Reference]
152628-03-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Light Yellow to Tan Powder | [Uses]
4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid is a useful synthetic intermediate,a useful compound in organic synthesis.
| [Synthesis]
Example 4: Methyl 3-methyl-4-butyrylamino-5-nitrobenzoate (II) (10 g, 0.036 mol) was suspended in 60 ml of water and heated to 70-80 °C. A suspension of sodium dithionite (21.75 g, 0.124 mol) in 60 ml of water was added slowly and heated to 90-100 °C. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 10-11 and the temperature was maintained with continued stirring until TLC detection showed complete disappearance of methyl 3-methyl-4-butyrylamino-5-nitrobenzoate. Subsequently, the pH of the reaction mixture was adjusted to 6-6.5. The resulting solid was filtered and dried at 45-50 °C to afford 2-n-propyl-4-methyl-6-carboxybenzimidazole (7.5 g, yield: 96.4%). | [References]
[1] Patent: WO2012/28925, 2012, A2. Location in patent: Page/Page column 18
[2] Journal of Heterocyclic Chemistry, 2003, vol. 40, # 6, p. 1107 - 1112
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 25, p. 4040 - 4051
[4] Patent: WO2012/28925, 2012, A2
[5] Organic Process Research and Development, 2007, vol. 11, # 1, p. 81 - 85 |
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