| Identification | Back Directory | [Name]
RS 25344 hydrochloride | [CAS]
152815-28-6 | [Synonyms]
RS 25344 HCl
1-(3-Nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione hydrochloride
memory,cognition,human,RS25344 hydrochloride,antineoplastic,RS-25344,Inhibitor,anti-inflammatory,RS 25344,inhibit,Phosphodiesterase (PDE),RS25344,RS 25344 hydrochloride,lymphocytes,cAMP | [Molecular Formula]
C19H14ClN5O4 | [MOL File]
152815-28-6.mol | [Molecular Weight]
411.8 |
| Hazard Information | Back Directory | [Uses]
RS 25344 Hydrochloride is a phosphdiesterase (PDE 4) inhibitor. | [in vivo]
RS-25344 hydrochloride (5 mg/kg; i.p.; twice daily for 72 h) results in significant increases in stomach weights in wild type C57BL/6 mice[3].
RS-25344 hydrochloride (1 mg/kg; i.p.; 30 min prior to food bolus) increases gastric retention in mice[3].
| [IC 50]
PDE Ⅳ: 0.28 nM (IC50); PDE Ⅰ: >100 μM (IC50); PDE Ⅱ: 160 μM (IC50); PDE Ⅲ: 330 μM (IC50) | [storage]
Desiccate at RT |
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BOC Sciences
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https://www.bocsci.com |
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