| Identification | Back Directory | [Name]
1H-Indole-3-methanamine, α-(4-methoxyphenyl)-2-methyl-N-[4-(trifluoromethyl)phenyl]- | [CAS]
1529814-60-5 | [Synonyms]
PS121912
PS-121912
PS 121912
1H-Indole-3-methanamine, α-(4-methoxyphenyl)-2-methyl-N-[4-(trifluoromethyl)phenyl]- | [Molecular Formula]
C24H21F3N2O | [MOL File]
1529814-60-5.mol | [Molecular Weight]
410.44 |
| Chemical Properties | Back Directory | [Boiling point ]
542.6±50.0 °C(Predicted) | [density ]
1.283±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
17.60±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
PS121912 is a potent and selective VDR-coactivator inhibitor. | [Uses]
PS121912 is a selective vitamin D receptor (VDR)-coregulator inhibitor. PS121912 has acceptable metabolic stability in vivo. PS121912 can be used for the research of cancer[1]. | [in vivo]
PS121912 shows an acceptable metabolic stability and can inhibit the metabolic enzyme CYP3A4 at higher concentrations in vivo cancer studies[1].
| [References]
[1] Sidhu PS, et al. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemother Pharmacol. 2014;74(4):787-798. DOI:10.1007/s00280-014-2549-y |
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